T cell receptor binding kinetics and special role of Valpha in T cell development and activation.


Journal Article (Review)

The kinetics of the interaction between T cell receptor (TCR) and major histocompatibility complex (MHC) has an important role in determining thymocyte-positive and -negative selection in the thymus, as well as in T cell activation. The alpha chain of the TCR is the major player in determining how the TCR fits onto the MHC ligand, and thus has a major role in determining whether a T cell develops as class I or class II restricted. In this article, we summarize recent data from our laboratory and others on the role of polymorphism in the Valpha combining site in determining MHC class restriction, and on kinetic parameters in thymocyte selection.

Full Text

Duke Authors

Cited Authors

  • Gascoigne, NR; Alam, SM; Lin, CM; McGuire, MV; Marine, S; Niederberger, N; Redpath, S; Sim, BC; Travers, PJ; Yachi, P; Zal, MA; Zal, T

Published Date

  • 2000

Published In

Volume / Issue

  • 21 / 2-3

Start / End Page

  • 225 - 231

PubMed ID

  • 10852121

Pubmed Central ID

  • 10852121

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/IR:21:2-3:225


  • eng

Conference Location

  • United States