Evaluation of the usefulness of open lung biopsies.


Journal Article

The role of open lung biopsy (OLB) in the diagnosis of the etiology of lung infiltrates in children was analyzed for a 10-year period 1979-1989 in a tertiary referral center. A total of 18 children had 19 lung biopsies to ascertain the cause of lung infiltrates. Thirteen of these children (72%) were immunocompromised due to treatment of hematological/solid malignancies and bone marrow transplantation. The clinical diagnosis was bilateral lung infiltrates of unknown etiology in 17 of 18 children. Eight of these children were ventilated for respiratory failure. The biopsy was useful in achieving a histological diagnosis in 18 of 19 samples (diagnostic yield 95%) and an etiological diagnosis in 14 of 19 samples (etiological yield 74%). Therapeutic strategy was altered in 14 of 18 patients based on the biopsy results. Five of 14 patients responded favorably to a change in specific treatment. The time interval from onset of respiratory illness to biopsy was 2-60 days (mean 16 days). Despite the critical state of these children there were few complications associated with the biopsy and no mortality directly related to the procedure. We recommend that OLB be undertaken sooner rather than later in immunocompromised children with bilateral pulmonary infiltrates of unknown etiology.

Full Text

Cited Authors

  • Gururangan, S; Lawson, RA; Jones, PH; Stevens, RF; Campbell, RH

Published Date

  • April 1, 1992

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 107 - 113

PubMed ID

  • 1524987

Pubmed Central ID

  • 1524987

Electronic International Standard Serial Number (EISSN)

  • 1521-0669

International Standard Serial Number (ISSN)

  • 0888-0018

Digital Object Identifier (DOI)

  • 10.3109/08880019209018326


  • eng