Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.

Journal Article (Journal Article)

A patient with a primary undifferentiated carcinoma of the nasopharynx manifested the clinical syndrome of inappropriate antidiuretic hormone secretion (SIADH). Immunohistochemical techniques demonstrated the presence of vasopressin, neurophysin, and their precursor (propressophysin) in the cancer cells. In situ hybridization additionally confirmed the expression of propressophysin messenger RNA in these cells. To the knowledge of the authors, this represents not only the first case of SIADH caused by carcinoma of the nasopharynx, but also the first report of pathologic confirmation of the syndrome with the use of both molecular and immunologic probes.

Full Text

Duke Authors

Cited Authors

  • Kavanagh, BD; Halperin, EC; Rosenbaum, LC; Shannon, EM; Nilaver, G

Published Date

  • March 15, 1992

Published In

Volume / Issue

  • 69 / 6

Start / End Page

  • 1315 - 1319

PubMed ID

  • 1540868

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>;2-2


  • eng

Conference Location

  • United States