Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment.


Journal Article

Pre- and postoperative computerized tomography scans, simulator films, and computerized tomography scans documenting tumor recurrence were analyzed on 70 patients with supratentorial malignant glioma treated with whole brain plus boost radiation therapy to determine sites of recurrence in relation to the boost. The boost was planned using the postoperative computerized tomography scan. Tumor recurred in 53 patients--within the boost in 38 (72%), partly outside the boost in 12 (23%), outside the boost but within the brain in one (2%), in the boost and in the spinal cord in one (2%), and in the spinal cord only in one (2%). All recurrences confined to the brain were found within 4 cm of the enhancing tumor as defined by the preoperative computerized tomography scan. Recurrences outside the boost were more common with inadequate boost margins, small boost volumes, temporal lobe tumors, and homolateral wedge pair technique. Survival was not adversely affected by recurrence outside the boost. We recommend that patients with malignant glioma be treated by parallel opposed fields with a margin that is 4 cm beyond the edge of the preoperative enhancing tumor, as seen on computerized tomography scan.

Full Text

Duke Authors

Cited Authors

  • Gaspar, LE; Fisher, BJ; Macdonald, DR; LeBer, DV; Halperin, EC; Schold, SC; Cairncross, JG

Published Date

  • 1992

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 55 - 57

PubMed ID

  • 1512163

Pubmed Central ID

  • 1512163

International Standard Serial Number (ISSN)

  • 0360-3016


  • eng

Conference Location

  • United States