Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.

Journal Article (Journal Article)

Thrombosis of the hepatic veins (Budd-Chiari syndrome) is a life-threatening thrombotic complication which can occur in patients with paroxysmal nocturnal haemoglobinuria (PNH). Despite aggressive medical and surgical therapy, mortality from Budd-Chiari syndrome remains high. We report a boy with PNH who developed Budd-Chiari syndrome and underwent syngeneic bone marrow transplantation (BMT). Now, 3 years following BMT, he has had dramatic clinical and radiographic evidence of resolution of the thrombosis. We suggest that BMT for PNH can successfully correct life-threatening thrombosis in patients with PNH.

Full Text

Duke Authors

Cited Authors

  • Graham, ML; Rosse, WF; Halperin, EC; Miller, CR; Ware, RE

Published Date

  • March 1996

Published In

Volume / Issue

  • 92 / 3

Start / End Page

  • 707 - 710

PubMed ID

  • 8616041

Pubmed Central ID

  • 8616041

International Standard Serial Number (ISSN)

  • 0007-1048

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.1996.365901.x

Language

  • eng

Conference Location

  • England