Palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins.

Published

Journal Article

Reaction of 5,5-dimethyl-8-nonene-2,4-dione catalyzed by PdCl2(CH3CN)2 (5 mol %) in the presence of CuCl2 (2.5 equiv) at room temperature for 3 h formed 2-acetyl-3,6,6-trimethyl-2-cyclohexenone in 96% isolated yield. Palladium-catalyzed intramolecular oxidative alkylation tolerated a range of substitution and was applicable to the synthesis of spirobicyclic compounds and to the cyclization of zeta-alkenyl beta-keto esters.

Full Text

Duke Authors

Cited Authors

  • Pei, T; Wang, X; Widenhoefer, RA

Published Date

  • January 2003

Published In

Volume / Issue

  • 125 / 3

Start / End Page

  • 648 - 649

PubMed ID

  • 12526661

Pubmed Central ID

  • 12526661

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja026317b

Language

  • eng