Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes

Journal Article

A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5-substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure α-amino acids related to homophenylalanine. © 2001 Published by Elsevier Science Ltd.

Full Text

Duke Authors

Cited Authors

  • Long, A; Baldwin, SW

Published Date

  • 2001

Published In

Volume / Issue

  • 42 / 32

Start / End Page

  • 5343 - 5345

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(01)00821-8