RNase H activation by stereoregular boranophosphate oligonucleotide.
Journal Article (Journal Article)
A stereoregular all-(Sp)-boranophosphate oligodeoxyribonucleotide (BH3(-)-ODN) 15-mer was synthesized using an enzymatic approach. The BH3(-)-ODN formed a hybrid with the complementary RNA 15-mer and induced RNase H hydrolysis of the RNA strand at ODN concentrations as low as 10 nM at 37 degrees C, but with a lower efficiency than that of its natural phosphodiester analogue.
- Wang, X; Dobrikov, M; Sergueev, D; Shaw, BR
- May 2003
Volume / Issue
- 22 / 5-8
Start / End Page
- 1151 - 1153
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)