Palladium-catalyzed intramolecular hydroalkylation of unactivated olefins with dialkyl ketones.
Published
Journal Article
[reaction: see text] Treatment of 3-butenyl heptyl ketone with substoichiometric amounts of PdCl(2)(CH(3)CN)(2) (10 mol %), HCl (0.1 equiv), and CuCl(2) (0.3 equiv) in dioxane at 70 degrees C for 12 h in a sealed tube formed 2-hexylcyclohexanone in 77% isolated yield. A number of alkyl 3-butenyl ketones underwent hydroalkylation under these conditions to form 2-substituted cyclohexanones in moderate to good yield.
Full Text
Duke Authors
Cited Authors
- Wang, X; Pei, T; Han, X; Widenhoefer, RA
Published Date
- July 2003
Published In
Volume / Issue
- 5 / 15
Start / End Page
- 2699 - 2701
PubMed ID
- 12868893
Pubmed Central ID
- 12868893
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7052
Digital Object Identifier (DOI)
- 10.1021/ol034879+
Language
- eng