Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex.

Published

Journal Article

[reaction: see text] Reaction of 4,4-dicarbomethoxy-1-octene-6-yne (1) with triethylsilane and a catalytic 1:1 mixture of [Rh(COD)(2)](+) SbF(6)(-) and (R)-BIPHEMP (5 mol %) at 70 degrees C for 90 min gave (Z)-1,1-dicarbomethoxy-3-(1-triethylsilyl)ethylidene-4-methylcyclopentane (2) in 81% isolated yield with 98% de and 92% ee.

Full Text

Duke Authors

Cited Authors

  • Chakrapani, H; Liu, C; Widenhoefer, RA

Published Date

  • January 2003

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 157 - 159

PubMed ID

  • 12529129

Pubmed Central ID

  • 12529129

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol027196n

Language

  • eng