Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate


Journal Article

The first boranophosphorothioate [(RO)2P(S)(BH3)-] mimic of a phosphodiester compound, dithymidine boranophosphorothioate, has been synthesized; while it is water soluble, this new analogue is more lipophilic and nuclease resistant than natural nucleoside phosphodiesters [(RO)2P(O)(O)-] and phosphorothioates [(RO)2P(S)(O)-].

Full Text

Duke Authors

Cited Authors

  • Lin, J; Shaw, BR

Published Date

  • August 21, 1999

Published In

Start / End Page

  • 1517 - 1518

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/a901157i

Citation Source

  • Scopus