Boranophosphate nucleic acids--a versatile DNA backbone.

Journal Article (Journal Article)

Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.

Full Text

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Duke Authors

Shaw, Barbara R.

Cited Authors

Rait, V; Sergueev, D; Summers, J; He, K; Huang, F; Krzyzanowska, B; Shaw, BR

Published Date

June 1999

Published In

Nucleosides and Nucleotides

Volume / Issue

18 / 6-7

Start / End Page

1379 - 1380

PubMed ID

10474223

International Standard Serial Number (ISSN)

0732-8311

Digital Object Identifier (DOI)

10.1080/07328319908044721

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