Boranophosphate nucleic acids--a versatile DNA backbone.

Published

Journal Article

Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.

Full Text

Duke Authors

Cited Authors

  • Rait, V; Sergueev, D; Summers, J; He, K; Huang, F; Krzyzanowska, B; Shaw, BR

Published Date

  • June 1999

Published In

Volume / Issue

  • 18 / 6-7

Start / End Page

  • 1379 - 1380

PubMed ID

  • 10474223

Pubmed Central ID

  • 10474223

International Standard Serial Number (ISSN)

  • 0732-8311

Digital Object Identifier (DOI)

  • 10.1080/07328319908044721

Language

  • eng