Boranophosphate nucleic acids--a versatile DNA backbone.
Journal Article (Journal Article)
Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.
Full Text
Duke Authors
Cited Authors
- Rait, V; Sergueev, D; Summers, J; He, K; Huang, F; Krzyzanowska, B; Shaw, BR
Published Date
- June 1999
Published In
Volume / Issue
- 18 / 6-7
Start / End Page
- 1379 - 1380
PubMed ID
- 10474223
International Standard Serial Number (ISSN)
- 0732-8311
Digital Object Identifier (DOI)
- 10.1080/07328319908044721
Language
- eng