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Boranophosphate nucleic acids--a versatile DNA backbone.

Publication ,  Journal Article
Rait, V; Sergueev, D; Summers, J; He, K; Huang, F; Krzyzanowska, B; Shaw, BR
Published in: Nucleosides & nucleotides
June 1999

Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.

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Published In

Nucleosides & nucleotides

DOI

ISSN

0732-8311

Publication Date

June 1999

Volume

18

Issue

6-7

Start / End Page

1379 / 1380

Related Subject Headings

  • Organophosphorus Compounds
  • Organic Chemistry
  • Nucleic Acids
  • Nucleic Acid Conformation
  • DNA
  • Crystallography, X-Ray
  • Boron Compounds
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Rait, V., Sergueev, D., Summers, J., He, K., Huang, F., Krzyzanowska, B., & Shaw, B. R. (1999). Boranophosphate nucleic acids--a versatile DNA backbone. Nucleosides & Nucleotides, 18(6–7), 1379–1380. https://doi.org/10.1080/07328319908044721
Rait, V., D. Sergueev, J. Summers, K. He, F. Huang, B. Krzyzanowska, and B. R. Shaw. “Boranophosphate nucleic acids--a versatile DNA backbone.Nucleosides & Nucleotides 18, no. 6–7 (June 1999): 1379–80. https://doi.org/10.1080/07328319908044721.
Rait V, Sergueev D, Summers J, He K, Huang F, Krzyzanowska B, et al. Boranophosphate nucleic acids--a versatile DNA backbone. Nucleosides & nucleotides. 1999 Jun;18(6–7):1379–80.
Rait, V., et al. “Boranophosphate nucleic acids--a versatile DNA backbone.Nucleosides & Nucleotides, vol. 18, no. 6–7, June 1999, pp. 1379–80. Epmc, doi:10.1080/07328319908044721.
Rait V, Sergueev D, Summers J, He K, Huang F, Krzyzanowska B, Shaw BR. Boranophosphate nucleic acids--a versatile DNA backbone. Nucleosides & nucleotides. 1999 Jun;18(6–7):1379–1380.

Published In

Nucleosides & nucleotides

DOI

ISSN

0732-8311

Publication Date

June 1999

Volume

18

Issue

6-7

Start / End Page

1379 / 1380

Related Subject Headings

  • Organophosphorus Compounds
  • Organic Chemistry
  • Nucleic Acids
  • Nucleic Acid Conformation
  • DNA
  • Crystallography, X-Ray
  • Boron Compounds
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology