Synthesis of a novel triphosphate analogue: Nucleoside α-P-borano, α-P-thiotriphosphate
The first boranothiotriphosphate compound, thymidine 5'-[α-P-borano, α-P-thio]triphosphate, in which borane and sulfur replace the two non-bridging oxygens of the α-phosphate in natural nucleoside triphosphates (NTPs), has been synthesized; some chemical properties of this borane-sulfur disubstituted nucleoside triphosphate analogue have been investigated. The synthetic approach reported here should be applicable for preparation of any α-borano, α-thio modified NTP or deoxy NTP; potential applications are discussed.
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