Synthesis of a novel triphosphate analogue: Nucleoside α-P-borano, α-P-thiotriphosphate


Journal Article

The first boranothiotriphosphate compound, thymidine 5'-[α-P-borano, α-P-thio]triphosphate, in which borane and sulfur replace the two non-bridging oxygens of the α-phosphate in natural nucleoside triphosphates (NTPs), has been synthesized; some chemical properties of this borane-sulfur disubstituted nucleoside triphosphate analogue have been investigated. The synthetic approach reported here should be applicable for preparation of any α-borano, α-thio modified NTP or deoxy NTP; potential applications are discussed.

Full Text

Duke Authors

Cited Authors

  • Lin, J; Shaw, BR

Published Date

  • November 7, 2000

Published In

Start / End Page

  • 2115 - 2116

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/b005059h

Citation Source

  • Scopus