Synthesis of new classes of boron-containing nucleotides.

Published

Journal Article

Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.

Full Text

Duke Authors

Cited Authors

  • Lin, J; Shaw, BR

Published Date

  • April 2001

Published In

Volume / Issue

  • 20 / 4-7

Start / End Page

  • 587 - 596

PubMed ID

  • 11563076

Pubmed Central ID

  • 11563076

Electronic International Standard Serial Number (EISSN)

  • 1532-2335

International Standard Serial Number (ISSN)

  • 1525-7770

Digital Object Identifier (DOI)

  • 10.1081/ncn-100002335

Language

  • eng