Synthesis of new classes of boron-containing nucleotides.

Journal Article (Journal Article)

Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Shaw, Barbara R.

Cited Authors

Lin, J; Shaw, BR

Published Date

April 2001

Published In

Nucleosides, Nucleotides & Nucleic Acids

Volume / Issue

20 / 4-7

Start / End Page

587 - 596

PubMed ID

11563076

Electronic International Standard Serial Number (EISSN)

1532-2335

International Standard Serial Number (ISSN)

1525-7770

Digital Object Identifier (DOI)

10.1081/ncn-100002335

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