Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection.
Journal Article
Short oligonucleoside boranophosphates containing all four nucleosides were synthesized on solid support using base-unprotected nucleoside H-phosphonate monomers. This strategy avoided irreversible base modifications during the boronation procedure. Structures of the boranophosphate oligomers were confirmed by 1H, 31P, 10B NMR and MS analysis as well as by enzymatic hydrolysis.
Full Text
Duke Authors
Cited Authors
- Sergueev, DS; Sergueeva, ZA; Shaw, BR
Published Date
- April 2001
Published In
Volume / Issue
- 20 / 4-7
Start / End Page
- 789 - 795
PubMed ID
- 11563117
Pubmed Central ID
- 11563117
Electronic International Standard Serial Number (EISSN)
- 1532-2335
International Standard Serial Number (ISSN)
- 1525-7770
Digital Object Identifier (DOI)
- 10.1081/ncn-100002431
Language
- eng