Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection.

Published

Journal Article

Short oligonucleoside boranophosphates containing all four nucleosides were synthesized on solid support using base-unprotected nucleoside H-phosphonate monomers. This strategy avoided irreversible base modifications during the boronation procedure. Structures of the boranophosphate oligomers were confirmed by 1H, 31P, 10B NMR and MS analysis as well as by enzymatic hydrolysis.

Full Text

Duke Authors

Cited Authors

  • Sergueev, DS; Sergueeva, ZA; Shaw, BR

Published Date

  • April 2001

Published In

Volume / Issue

  • 20 / 4-7

Start / End Page

  • 789 - 795

PubMed ID

  • 11563117

Pubmed Central ID

  • 11563117

Electronic International Standard Serial Number (EISSN)

  • 1532-2335

International Standard Serial Number (ISSN)

  • 1525-7770

Digital Object Identifier (DOI)

  • 10.1081/ncn-100002431

Language

  • eng