Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection.

Journal Article (Journal Article)

Short oligonucleoside boranophosphates containing all four nucleosides were synthesized on solid support using base-unprotected nucleoside H-phosphonate monomers. This strategy avoided irreversible base modifications during the boronation procedure. Structures of the boranophosphate oligomers were confirmed by 1H, 31P, 10B NMR and MS analysis as well as by enzymatic hydrolysis.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Shaw, Barbara R.

Cited Authors

Sergueev, DS; Sergueeva, ZA; Shaw, BR

Published Date

April 2001

Published In

Nucleosides, Nucleotides & Nucleic Acids

Volume / Issue

20 / 4-7

Start / End Page

789 - 795

PubMed ID

11563117

Electronic International Standard Serial Number (EISSN)

1532-2335

International Standard Serial Number (ISSN)

1525-7770

Digital Object Identifier (DOI)

10.1081/ncn-100002431

Scholars@Duke