Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs.

Published

Journal Article

A new method for synthesis of N-alkylated nucleosides was developed. Exceptionally mild and selective conversion of N-acyl to the corresponding N-alkyl nucleosides was achieved by reduction with borane-amine complexes. The borane-amine complexes were also used as efficient scavengers of a 4,4'-dimethoxytrityl (DMT) cation. Neutralization of the cation eliminated the boranophosphate group degradation during acidic DMT deprotection and allowed milder acidic conditions for the deprotection.

Full Text

Duke Authors

Cited Authors

  • Sergueeva, ZA; Sergueev, DS; Shaw, BR

Published Date

  • April 2001

Published In

Volume / Issue

  • 20 / 4-7

Start / End Page

  • 941 - 945

PubMed ID

  • 11563150

Pubmed Central ID

  • 11563150

Electronic International Standard Serial Number (EISSN)

  • 1532-2335

International Standard Serial Number (ISSN)

  • 1525-7770

Digital Object Identifier (DOI)

  • 10.1081/ncn-100002464

Language

  • eng