Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs.
Publication
, Journal Article
Sergueeva, ZA; Sergueev, DS; Shaw, BR
Published in: Nucleosides, nucleotides & nucleic acids
April 2001
A new method for synthesis of N-alkylated nucleosides was developed. Exceptionally mild and selective conversion of N-acyl to the corresponding N-alkyl nucleosides was achieved by reduction with borane-amine complexes. The borane-amine complexes were also used as efficient scavengers of a 4,4'-dimethoxytrityl (DMT) cation. Neutralization of the cation eliminated the boranophosphate group degradation during acidic DMT deprotection and allowed milder acidic conditions for the deprotection.
Duke Scholars
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
941 / 945
Related Subject Headings
- Trityl Compounds
- Reducing Agents
- Organic Chemistry
- Nucleosides
- Boranes
- Amines
- Alkylation
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Sergueeva, Z. A., Sergueev, D. S., & Shaw, B. R. (2001). Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs. Nucleosides, Nucleotides & Nucleic Acids, 20(4–7), 941–945. https://doi.org/10.1081/ncn-100002464
Sergueeva, Z. A., D. S. Sergueev, and B. R. Shaw. “Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs.” Nucleosides, Nucleotides & Nucleic Acids 20, no. 4–7 (April 2001): 941–45. https://doi.org/10.1081/ncn-100002464.
Sergueeva ZA, Sergueev DS, Shaw BR. Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):941–5.
Sergueeva, Z. A., et al. “Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs.” Nucleosides, Nucleotides & Nucleic Acids, vol. 20, no. 4–7, Apr. 2001, pp. 941–45. Epmc, doi:10.1081/ncn-100002464.
Sergueeva ZA, Sergueev DS, Shaw BR. Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):941–945.
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
941 / 945
Related Subject Headings
- Trityl Compounds
- Reducing Agents
- Organic Chemistry
- Nucleosides
- Boranes
- Amines
- Alkylation
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology