Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.
Journal Article (Journal Article)
A new type of non-ionic nucleotide analogue with a doubly modified internucleotide linkage, P-boranomethylphosphonate, has been successfully synthesized and characterized. Dithymidine boranomethylphosphonate 5 is the first example of a P-boranomethylphosphonate compound; it is a highly lipophilic phosphodiester analog, which is almost totally resistant to both snake venom phosphodiesterase (SVPDE) and bovine spleen phosphodiesterase (BSPDE). P-boranomethylphosphonates are expected to be promising candidates for mechanistic, diagnostic and therapeutic applications.
Full Text
Duke Authors
Cited Authors
- Lin, J; Shaw, BR
Published Date
- April 2001
Published In
Volume / Issue
- 20 / 4-7
Start / End Page
- 1325 - 1328
PubMed ID
- 11563014
Electronic International Standard Serial Number (EISSN)
- 1532-2335
International Standard Serial Number (ISSN)
- 1525-7770
Digital Object Identifier (DOI)
- 10.1081/ncn-100002547
Language
- eng