Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.

Journal Article

A new type of non-ionic nucleotide analogue with a doubly modified internucleotide linkage, P-boranomethylphosphonate, has been successfully synthesized and characterized. Dithymidine boranomethylphosphonate 5 is the first example of a P-boranomethylphosphonate compound; it is a highly lipophilic phosphodiester analog, which is almost totally resistant to both snake venom phosphodiesterase (SVPDE) and bovine spleen phosphodiesterase (BSPDE). P-boranomethylphosphonates are expected to be promising candidates for mechanistic, diagnostic and therapeutic applications.

Full Text

Duke Authors

Cited Authors

  • Lin, J; Shaw, BR

Published Date

  • April 2001

Published In

Volume / Issue

  • 20 / 4-7

Start / End Page

  • 1325 - 1328

PubMed ID

  • 11563014

International Standard Serial Number (ISSN)

  • 1525-7770

Digital Object Identifier (DOI)

  • 10.1081/NCN-100002547

Language

  • eng

Conference Location

  • United States