Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.
Journal Article (Journal Article)
[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.
Full Text
Duke Authors
Cited Authors
- Li, P; Shaw, BR
Published Date
- June 2002
Published In
Volume / Issue
- 4 / 12
Start / End Page
- 2009 - 2012
PubMed ID
- 12049504
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/ol025832b
Language
- eng