Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.

Journal Article (Journal Article)

[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Shaw, Barbara R.

Cited Authors

Li, P; Shaw, BR

Published Date

June 2002

Published In

Organic Letters

Volume / Issue

4 / 12

Start / End Page

2009 - 2012

PubMed ID

12049504

Electronic International Standard Serial Number (EISSN)

1523-7052

International Standard Serial Number (ISSN)

1523-7060

Digital Object Identifier (DOI)

10.1021/ol025832b

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