Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.

Journal Article (Journal Article)

[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.

Full Text

Duke Authors

Cited Authors

  • Li, P; Shaw, BR

Published Date

  • June 2002

Published In

Volume / Issue

  • 4 / 12

Start / End Page

  • 2009 - 2012

PubMed ID

  • 12049504

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol025832b


  • eng