Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide.

Published

Journal Article

The first examples of a borane-containing doubly P-modified chiral cyclic nucleoside monophosphate (cNMP), e.g., thymidine and 5-fluoro-2'-deoxyuridine 3',5'-cyclic boranophosphorothioates, have been synthesized; these cNMP analogues with increased lipophilicity could be potential anticancer prodrugs and useful probes for mechanistic studies.

Full Text

Duke Authors

Cited Authors

  • Li, P; Shaw, BR

Published Date

  • December 2002

Published In

Start / End Page

  • 2890 - 2891

PubMed ID

  • 12478798

Pubmed Central ID

  • 12478798

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/b207350a

Language

  • eng