Protein farnesyltransferase.
Journal Article (Journal Article;Review)
In the past year, the crystal structure of alpha beta heterodimeric protein farnesyltransferase from rat was reported to a resolution of 2.25 A. Farnesyltransferase catalyzes the essential post-translational lipidation of Ras and several other cellular signal transduction proteins. The structure provides a foundation for understanding the specificity and mechanism of protein prenylation and may aid in the design of new anticancer therapeutics.
Full Text
Duke Authors
Cited Authors
- Park, HW; Beese, LS
Published Date
- December 1997
Published In
Volume / Issue
- 7 / 6
Start / End Page
- 873 - 880
PubMed ID
- 9434909
International Standard Serial Number (ISSN)
- 0959-440X
Digital Object Identifier (DOI)
- 10.1016/s0959-440x(97)80160-1
Language
- eng
Conference Location
- England