Protein farnesyltransferase.

Journal Article (Journal Article;Review)

In the past year, the crystal structure of alpha beta heterodimeric protein farnesyltransferase from rat was reported to a resolution of 2.25 A. Farnesyltransferase catalyzes the essential post-translational lipidation of Ras and several other cellular signal transduction proteins. The structure provides a foundation for understanding the specificity and mechanism of protein prenylation and may aid in the design of new anticancer therapeutics.

Full Text

Duke Authors

Cited Authors

  • Park, HW; Beese, LS

Published Date

  • December 1997

Published In

Volume / Issue

  • 7 / 6

Start / End Page

  • 873 - 880

PubMed ID

  • 9434909

International Standard Serial Number (ISSN)

  • 0959-440X

Digital Object Identifier (DOI)

  • 10.1016/s0959-440x(97)80160-1

Language

  • eng

Conference Location

  • England