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The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives.

Publication ,  Journal Article
Sood, A; Shaw, BR; Spielvogel, BF; Hall, ES; Chi, LK; Hall, IH
Published in: Die Pharmazie
November 1992

N2-Isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives were observed to be potent antineoplastic agents and to be active against a number of human tissue culture tumor cells, e.g. Tmolt3 leukemia, HeLa-S3 uterine carcinoma. Selective agents were active against colon adenocarcinoma, osteosarcoma and glioma growth. These agents preferentially inhibited both DNA and RNA synthesis of L1210 cells. De novo synthesis of purines was significantly inhibited at the regulatory sites of PRPP amido transferase and IMP dehydrogenase. Other sites of inhibition were thymidylate synthetase, OMP decarboxylase and thymidine kinases. The agents also significantly reduced deoxyribonucleotide levels and caused DNA strand scission.

Duke Scholars

Published In

Die Pharmazie

ISSN

0031-7144

Publication Date

November 1992

Volume

47

Issue

11

Start / End Page

833 / 838

Related Subject Headings

  • Tumor Cells, Cultured
  • RNA, Neoplasm
  • Pharmacology & Pharmacy
  • Neoplasm Proteins
  • Mice, Inbred C57BL
  • Mice
  • Leukemia L1210
  • Humans
  • Deoxyguanosine
  • DNA, Neoplasm
 

Citation

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MLA
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Sood, A., Shaw, B. R., Spielvogel, B. F., Hall, E. S., Chi, L. K., & Hall, I. H. (1992). The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. Die Pharmazie, 47(11), 833–838.
Sood, A., B. R. Shaw, B. F. Spielvogel, E. S. Hall, L. K. Chi, and I. H. Hall. “The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives.Die Pharmazie 47, no. 11 (November 1992): 833–38.
Sood A, Shaw BR, Spielvogel BF, Hall ES, Chi LK, Hall IH. The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. Die Pharmazie. 1992 Nov;47(11):833–8.
Sood, A., et al. “The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives.Die Pharmazie, vol. 47, no. 11, Nov. 1992, pp. 833–38.
Sood A, Shaw BR, Spielvogel BF, Hall ES, Chi LK, Hall IH. The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. Die Pharmazie. 1992 Nov;47(11):833–838.

Published In

Die Pharmazie

ISSN

0031-7144

Publication Date

November 1992

Volume

47

Issue

11

Start / End Page

833 / 838

Related Subject Headings

  • Tumor Cells, Cultured
  • RNA, Neoplasm
  • Pharmacology & Pharmacy
  • Neoplasm Proteins
  • Mice, Inbred C57BL
  • Mice
  • Leukemia L1210
  • Humans
  • Deoxyguanosine
  • DNA, Neoplasm