The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives.

Published

Journal Article

N2-Isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives were observed to be potent antineoplastic agents and to be active against a number of human tissue culture tumor cells, e.g. Tmolt3 leukemia, HeLa-S3 uterine carcinoma. Selective agents were active against colon adenocarcinoma, osteosarcoma and glioma growth. These agents preferentially inhibited both DNA and RNA synthesis of L1210 cells. De novo synthesis of purines was significantly inhibited at the regulatory sites of PRPP amido transferase and IMP dehydrogenase. Other sites of inhibition were thymidylate synthetase, OMP decarboxylase and thymidine kinases. The agents also significantly reduced deoxyribonucleotide levels and caused DNA strand scission.

Full Text

Duke Authors

Cited Authors

  • Sood, A; Shaw, BR; Spielvogel, BF; Hall, ES; Chi, LK; Hall, IH

Published Date

  • November 1992

Published In

Volume / Issue

  • 47 / 11

Start / End Page

  • 833 - 838

PubMed ID

  • 1492112

Pubmed Central ID

  • 1492112

International Standard Serial Number (ISSN)

  • 0031-7144

Language

  • eng