Hypolipidemic activity of boronated nucleosides and nucleotides in rodents.

Published

Journal Article

Base-boronated nucleoside and phosphate-boronated nucleotides were potent hypolipidemic agents in rodents, lowering both serum cholesterol and triglyceride levels. Rat VLDL and LDL cholesterol levels were generally reduced and HDL cholesterol levels were significantly elevated after 14 days dosing at 8 mg/kg/day. Tissue cholesterol, triglyceride and phospholipid levels were reduced by selected derivatives. Increased fecal excretion of lipids did not appear to be a mechanism by which these derivatives lowered serum lipids in rodents. Rather, the agents suppressed appetite and reduced the activities of rate-limiting enzymes for de novo lipid synthesis, specifically cytoplasmic acetyl CoA synthetase, squalene synthetase, and phosphatidylate phosphohydrolase with IC50 values of approximately 10(-5) m.

Full Text

Duke Authors

Cited Authors

  • Hall, IH; Burnham, BS; Rajendran, KG; Chen, SY; Sood, A; Spielvogel, BF; Shaw, BR

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 47 / 2-3

Start / End Page

  • 79 - 87

PubMed ID

  • 8218953

Pubmed Central ID

  • 8218953

Electronic International Standard Serial Number (EISSN)

  • 1950-6007

International Standard Serial Number (ISSN)

  • 0753-3322

Digital Object Identifier (DOI)

  • 10.1016/0753-3322(93)90295-v

Language

  • eng