Palladium-catalyzed oxidative alkoxylation of alpha-alkenyl beta-diketones to form functionalized furans.

Published

Journal Article

Treatment of 4-allyl-2,6-dimethyl-3,5-heptanedione with a catalytic amount of PdCl(2)(CH(3)CN)(2) (5 mol %) and a stoichiometric amount of CuCl(2) (2.2 equiv) in dioxane at 60 degrees C for 12 h formed 3-isobutyryl-2-isopropyl-5-methylfuran in 77% isolated yield. A number of alpha-alkenyl beta-diketones underwent oxidative alkoxylation under these conditions to form 2,3,5-trisubsituted furans in moderate to good yield.

Full Text

Duke Authors

Cited Authors

  • Han, X; Widenhoefer, RA

Published Date

  • March 2004

Published In

Volume / Issue

  • 69 / 5

Start / End Page

  • 1738 - 1740

PubMed ID

  • 14987038

Pubmed Central ID

  • 14987038

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo035576w

Language

  • eng