Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.

Journal Article (Journal Article)

A series of amine cyanoboranes and amine carboxyboranes were observed to be antihyperlipidemic agents in mice; i.e., they lowered serum cholesterol and triglyceride levels significantly. These compounds appeared to inhibit lipid synthesis in the early stages. The ability to lower serum cholesterol levels appeared to correlate with the suppression of the regulatory enzyme of cholesterol synthesis, beta-hydroxy-beta-methylglutaryl-CoA reductase activity. The reduction of serum triglycerides correlated with ability of the borane compound to suppress liver fatty acid synthetase activity.

Full Text

Duke Authors

Cited Authors

  • Hall, IH; Das, MK; Harchelroad, F; Wisian-Neilson, P; McPhail, AT; Spielvogel, BF

Published Date

  • March 1, 1981

Published In

Volume / Issue

  • 70 / 3

Start / End Page

  • 339 - 341

PubMed ID

  • 6115048

Electronic International Standard Serial Number (EISSN)

  • 1520-6017

International Standard Serial Number (ISSN)

  • 0022-3549

Digital Object Identifier (DOI)

  • 10.1002/jps.2600700333


  • eng