Synthesis of racemic, 2-(alkylthio)-6-(1-hydroxyethyl) penems; attempted penem synthesis via copper (I) - promoted cyclisations
Journal Article (Journal Article)
Stereocontrolled syntheses of the diastereoisomeric 6-(1-hydroxyethyl)-2-ethylthio and 2-(2-aminoethylthio)-penem-3-carboxylates from a common monocyclic azetidinone precursor are described. Cu (I)-promoted cyclisation of suitable N/C-3 secopenems is shown to yield "isopenems" (7-oxo-2-thia-1-azabicyc1o[3.2.0]-hept-3-enes) as the sole bicyclic product. © 1981.
Full Text
Duke Authors
Cited Authors
- McCombie, SW; Ganguly, AK; Girijavallabhan, VM; Jeffrey, PD; Lin, S; Pinto, P; McPhail, AT
Published Date
- January 1, 1981
Published In
Volume / Issue
- 22 / 36
Start / End Page
- 3489 - 3492
International Standard Serial Number (ISSN)
- 0040-4039
Digital Object Identifier (DOI)
- 10.1016/S0040-4039(01)81939-0
Citation Source
- Scopus