Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines.

Published

Journal Article

A novel class of antiulcer agents, the substituted imidazo[1,2-a]pyridines, is described. The present compounds are not histamine (H2) receptor antagonists nor are they prostaglandin analogues, yet they exhibit both gastric antisecretory and cytoprotective properties. The mechanism of gastric antisecretory activity may involve inhibition of the H+/K+-ATPase enzyme. Structure-activity studies led to the identification of 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine, SCH 28080 (27), which was selected for further development and clinical evaluation.

Full Text

Duke Authors

Cited Authors

  • Kaminski, JJ; Bristol, JA; Puchalski, C; Lovey, RG; Elliott, AJ; Guzik, H; Solomon, DM; Conn, DJ; Domalski, MS; Wong, SC

Published Date

  • July 1, 1985

Published In

Volume / Issue

  • 28 / 7

Start / End Page

  • 876 - 892

PubMed ID

  • 4009611

Pubmed Central ID

  • 4009611

Electronic International Standard Serial Number (EISSN)

  • 1520-4804

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00145a006

Language

  • eng