Practical Conversion of Artemisinic Acid into Desoxyartemisinin
Artemisinin (Qinghaosu, 2) isolated from Artemisia annua has recently been used in China as a new type of antimalarial drug with rapid action and low toxicity against chloroquine-resistant malaria. Artemisinin is a novel sesquiterpene lactone bearing an unusual cyclic peroxide function. The combination of an interesting biological activity, a novel chemical structure, and a low yield from natural sources prompted us to search for a new synthesis of artemisinin and related compounds. Although interesting syntheses of artemisinin and desoxyartemisinin were reported recently, these complex syntheses do not provide feasible methods for large-scale production. © 1986, American Chemical Society. All rights reserved.
Jung, M; ElSohly, HN; Croom, EM; McPhail, AT; McPhail, DR
Volume / Issue
Start / End Page
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)