Practical Conversion of Artemisinic Acid into Desoxyartemisinin

Journal Article (Journal Article)

Artemisinin (Qinghaosu, 2) isolated from Artemisia annua has recently been used in China as a new type of antimalarial drug with rapid action and low toxicity against chloroquine-resistant malaria. Artemisinin is a novel sesquiterpene lactone bearing an unusual cyclic peroxide function. The combination of an interesting biological activity, a novel chemical structure, and a low yield from natural sources prompted us to search for a new synthesis of artemisinin and related compounds. Although interesting syntheses of artemisinin and desoxyartemisinin were reported recently, these complex syntheses do not provide feasible methods for large-scale production. © 1986, American Chemical Society. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Jung, M; ElSohly, HN; Croom, EM; McPhail, AT; McPhail, DR

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 51 / 26

Start / End Page

  • 5417 - 5419

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo00376a070

Citation Source

  • Scopus