Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis.

Journal Article (Journal Article)

The structure of neihumicin, a new antibiotic isolated from the fermentation broth of Micromonospora neihuensis Wu, sp. nov., has been determined as (Z)-3,(Z)-6-dibenzylidene-2-methoxy-3,6-dihydropyrazin-5-one based upon spectral evidence and X-ray crystallographic analysis. Its total synthesis has also been achieved.

Full Text

Duke Authors

Cited Authors

  • Yang, LM; Wu, RY; McPhail, AT; Yokoi, T; Lee, KH

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 488 - 493

PubMed ID

  • 3372355

Pubmed Central ID

  • 3372355

Electronic International Standard Serial Number (EISSN)

  • 1881-1469

International Standard Serial Number (ISSN)

  • 0021-8820

Digital Object Identifier (DOI)

  • 10.7164/antibiotics.41.488

Language

  • eng