Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).

Journal Article (Journal Article)

Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella typhimurium strains T-98 and T-100. Both compounds exhibited strong inhibition of the mutagenicity of 2-aminoanthracene and ethyl methanesulfonate toward, respectively, the T-98 strain plus a metabolic activator and T-100.

Full Text

Duke Authors

Cited Authors

  • Wall, ME; Wani, MC; Manikumar, G; Taylor, H; Hughes, TJ; Gaetano, K; Gerwick, HW; McPhail, AT; McPhail, DR

Published Date

  • September 1989

Published In

Volume / Issue

  • 52 / 5

Start / End Page

  • 1092 - 1099

PubMed ID

  • 2691635

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np50065a028


  • eng