The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.
The styrylpyrone, goniodiol-7-monoacetate  [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.
Wu, YC; Duh, CY; Chang, FR; Chang, GY; Wang, SK; Chang, JJ; McPhail, DR; McPhail, AT; Lee, KH
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