The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.

Journal Article (Journal Article)

The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.

Full Text

Duke Authors

Cited Authors

  • Wu, YC; Duh, CY; Chang, FR; Chang, GY; Wang, SK; Chang, JJ; McPhail, DR; McPhail, AT; Lee, KH

Published Date

  • July 1991

Published In

Volume / Issue

  • 54 / 4

Start / End Page

  • 1077 - 1081

PubMed ID

  • 1791473

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np50076a024


  • eng