Total Synthesis of Griseolic Acid Derivatives from D-Glucose
Griseolic acid, 1, is a potent nonselective cyclic nucleotide-phosphodiesterase inhibitor isolated from Streptomyces Griseoaurantiacus. Recently, preparation of several griseolic acid derivatives, including 3, has been reported. We have completed the chiral total synthesis of several griseolic acid derivatives. Here, we report on total syntheses of two cis-fused 4′,5′-dihydro-7′-deoxy griseolic acid derivatives, 4 and 5, from D-glucose. © 1991, American Chemical Society. All rights reserved.
Tulshian, D; Doll, RJ; Stansberry, MF; McPhail, AT
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