Total Synthesis of Griseolic Acid Derivatives from D-Glucose

Journal Article (Journal Article)

Griseolic acid, 1, is a potent nonselective cyclic nucleotide-phosphodiesterase inhibitor isolated from Streptomyces Griseoaurantiacus. Recently, preparation of several griseolic acid derivatives, including 3, has been reported. We have completed the chiral total synthesis of several griseolic acid derivatives. Here, we report on total syntheses of two cis-fused 4′,5′-dihydro-7′-deoxy griseolic acid derivatives, 4 and 5, from D-glucose. © 1991, American Chemical Society. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Tulshian, D; Doll, RJ; Stansberry, MF; McPhail, AT

Published Date

  • November 1, 1991

Published In

Volume / Issue

  • 56 / 24

Start / End Page

  • 6819 - 6822

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo00024a022

Citation Source

  • Scopus