Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.
Journal Article
Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.
Full Text
Duke Authors
Cited Authors
- Chen, K; Shi, Q; Kashiwada, Y; Zhang, DC; Hu, CQ; Jin, JQ; Nozaki, H; Kilkuskie, RE; Tramontano, E; Cheng, YC
Published Date
- March 1992
Published In
Volume / Issue
- 55 / 3
Start / End Page
- 340 - 346
PubMed ID
- 1375626
Pubmed Central ID
- 1375626
Electronic International Standard Serial Number (EISSN)
- 1520-6025
International Standard Serial Number (ISSN)
- 0163-3864
Digital Object Identifier (DOI)
- 10.1021/np50081a010
Language
- eng