Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.

Journal Article

Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.

Full Text

Duke Authors

Cited Authors

  • Chen, K; Shi, Q; Kashiwada, Y; Zhang, DC; Hu, CQ; Jin, JQ; Nozaki, H; Kilkuskie, RE; Tramontano, E; Cheng, YC

Published Date

  • March 1992

Published In

Volume / Issue

  • 55 / 3

Start / End Page

  • 340 - 346

PubMed ID

  • 1375626

Pubmed Central ID

  • 1375626

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np50081a010

Language

  • eng