Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.

Published

Journal Article

Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.

Full Text

Duke Authors

Cited Authors

  • Wall, ME; Wani, MC; Fullas, F; Oswald, JB; Brown, DM; Santisuk, T; Reutrakul, V; McPhail, AT; Farnsworth, NR; Pezzuto, JM

Published Date

  • May 1994

Published In

Volume / Issue

  • 37 / 10

Start / End Page

  • 1465 - 1470

PubMed ID

  • 8182705

Pubmed Central ID

  • 8182705

Electronic International Standard Serial Number (EISSN)

  • 1520-4804

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00036a012

Language

  • eng