Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.
Publication
, Journal Article
Wall, ME; Wani, MC; Fullas, F; Oswald, JB; Brown, DM; Santisuk, T; Reutrakul, V; McPhail, AT; Farnsworth, NR; Pezzuto, JM
Published in: Journal of medicinal chemistry
May 1994
Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.
Duke Scholars
Published In
Journal of medicinal chemistry
DOI
EISSN
1520-4804
ISSN
0022-2623
Publication Date
May 1994
Volume
37
Issue
10
Start / End Page
1465 / 1470
Related Subject Headings
- Tumor Cells, Cultured
- Molecular Conformation
- Models, Molecular
- Mice
- Medicinal & Biomolecular Chemistry
- Humans
- Flavonoids
- Drug Screening Assays, Antitumor
- Benzopyrans
- Antineoplastic Agents, Phytogenic
Citation
APA
Chicago
ICMJE
MLA
NLM
Wall, M. E., Wani, M. C., Fullas, F., Oswald, J. B., Brown, D. M., Santisuk, T., … Pezzuto, J. M. (1994). Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of Medicinal Chemistry, 37(10), 1465–1470. https://doi.org/10.1021/jm00036a012
Wall, M. E., M. C. Wani, F. Fullas, J. B. Oswald, D. M. Brown, T. Santisuk, V. Reutrakul, A. T. McPhail, N. R. Farnsworth, and J. M. Pezzuto. “Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.” Journal of Medicinal Chemistry 37, no. 10 (May 1994): 1465–70. https://doi.org/10.1021/jm00036a012.
Wall ME, Wani MC, Fullas F, Oswald JB, Brown DM, Santisuk T, et al. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of medicinal chemistry. 1994 May;37(10):1465–70.
Wall, M. E., et al. “Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.” Journal of Medicinal Chemistry, vol. 37, no. 10, May 1994, pp. 1465–70. Epmc, doi:10.1021/jm00036a012.
Wall ME, Wani MC, Fullas F, Oswald JB, Brown DM, Santisuk T, Reutrakul V, McPhail AT, Farnsworth NR, Pezzuto JM. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of medicinal chemistry. 1994 May;37(10):1465–1470.
Published In
Journal of medicinal chemistry
DOI
EISSN
1520-4804
ISSN
0022-2623
Publication Date
May 1994
Volume
37
Issue
10
Start / End Page
1465 / 1470
Related Subject Headings
- Tumor Cells, Cultured
- Molecular Conformation
- Models, Molecular
- Mice
- Medicinal & Biomolecular Chemistry
- Humans
- Flavonoids
- Drug Screening Assays, Antitumor
- Benzopyrans
- Antineoplastic Agents, Phytogenic