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Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.

Publication ,  Journal Article
Wall, ME; Wani, MC; Fullas, F; Oswald, JB; Brown, DM; Santisuk, T; Reutrakul, V; McPhail, AT; Farnsworth, NR; Pezzuto, JM
Published in: Journal of medicinal chemistry
May 1994

Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.

Duke Scholars

Published In

Journal of medicinal chemistry

DOI

EISSN

1520-4804

ISSN

0022-2623

Publication Date

May 1994

Volume

37

Issue

10

Start / End Page

1465 / 1470

Related Subject Headings

  • Tumor Cells, Cultured
  • Molecular Conformation
  • Models, Molecular
  • Mice
  • Medicinal & Biomolecular Chemistry
  • Humans
  • Flavonoids
  • Drug Screening Assays, Antitumor
  • Benzopyrans
  • Antineoplastic Agents, Phytogenic
 

Citation

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Wall, M. E., Wani, M. C., Fullas, F., Oswald, J. B., Brown, D. M., Santisuk, T., … Pezzuto, J. M. (1994). Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of Medicinal Chemistry, 37(10), 1465–1470. https://doi.org/10.1021/jm00036a012
Wall, M. E., M. C. Wani, F. Fullas, J. B. Oswald, D. M. Brown, T. Santisuk, V. Reutrakul, A. T. McPhail, N. R. Farnsworth, and J. M. Pezzuto. “Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.Journal of Medicinal Chemistry 37, no. 10 (May 1994): 1465–70. https://doi.org/10.1021/jm00036a012.
Wall ME, Wani MC, Fullas F, Oswald JB, Brown DM, Santisuk T, et al. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of medicinal chemistry. 1994 May;37(10):1465–70.
Wall, M. E., et al. “Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.Journal of Medicinal Chemistry, vol. 37, no. 10, May 1994, pp. 1465–70. Epmc, doi:10.1021/jm00036a012.
Wall ME, Wani MC, Fullas F, Oswald JB, Brown DM, Santisuk T, Reutrakul V, McPhail AT, Farnsworth NR, Pezzuto JM. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. Journal of medicinal chemistry. 1994 May;37(10):1465–1470.
Journal cover image

Published In

Journal of medicinal chemistry

DOI

EISSN

1520-4804

ISSN

0022-2623

Publication Date

May 1994

Volume

37

Issue

10

Start / End Page

1465 / 1470

Related Subject Headings

  • Tumor Cells, Cultured
  • Molecular Conformation
  • Models, Molecular
  • Mice
  • Medicinal & Biomolecular Chemistry
  • Humans
  • Flavonoids
  • Drug Screening Assays, Antitumor
  • Benzopyrans
  • Antineoplastic Agents, Phytogenic