Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras

Journal Article (Journal Article)

A series of pyrazolo[3,4-b]quinoline ribofuranosides were prepared using the glycosylation methodology of Vorbruggen. Oxidative cleavage of the ribose moiety in 6 furnished the dialdehyde intermediate 36, which cyclizes upon reductive amination providing the morpholino compound 37. Derivatives from both the ribose and morpholino series were evaluated for their ability to inhibit the nucleotide exchange process of oncogenic Ras.

Full Text

Duke Authors

Cited Authors

  • Wolin, R; Wang, D; Kelly, J; Afonso, A; James, L; Kirschmeier, P; McPhail, AT

Published Date

  • January 23, 1996

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 195 - 200

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/0960-894X(95)00574-D

Citation Source

  • Scopus