A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli

Journal Article (Journal Article)

A previously described cembranolide diterpene from Lobophytum cristagalli was identified as a potent (IC50 0.15 μM) inhibitor of farnesyl protein transferase (FPT). The compound showed selectivity for FPT as compared to the closely related enzyme geranylgeranyl protein transferase-1 (IC50 5.3 μM). Kinetic evaluation suggests that this compound competes with the protein/peptide farnesyl acceptor substrate, and not with farnesyl pyrophosphate for inhibition of FPT.

Full Text

Duke Authors

Cited Authors

  • Coval, SJ; Patton, RW; Petrin, JM; James, L; Rothofsky, ML; Lin, SL; Patel, M; Reed, JK; McPhail, AT; Bishop, WR

Published Date

  • April 9, 1996

Published In

Volume / Issue

  • 6 / 7

Start / End Page

  • 909 - 912

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/0960-894X(96)00142-4

Citation Source

  • Scopus