Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA(B) antagonists

Journal Article (Journal Article)

The synthesis and GABA(B) antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X- ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.

Full Text

Duke Authors

Cited Authors

  • Blythin, DJ; Kuo, SC; Shue, HJ; McPhail, AT; Chapman, RW; Kreutner, W; Rizzo, C; She, HS; West, R

Published Date

  • July 9, 1996

Published In

Volume / Issue

  • 6 / 13

Start / End Page

  • 1529 - 1534

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/S0960-894X(96)00267-3

Citation Source

  • Scopus