Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA(B) antagonists
Published
Journal Article
The synthesis and GABA(B) antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X- ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.
Full Text
Duke Authors
Cited Authors
- Blythin, DJ; Kuo, SC; Shue, HJ; McPhail, AT; Chapman, RW; Kreutner, W; Rizzo, C; She, HS; West, R
Published Date
- July 9, 1996
Published In
Volume / Issue
- 6 / 13
Start / End Page
- 1529 - 1534
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/S0960-894X(96)00267-3
Citation Source
- Scopus