Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors

Journal Article (Journal Article)

The C-3 sidechain of azetidinones related to SCH 48461 was modified by introducing a hydroxyl group at the 1' position. This led to the discovery of the cis azetidinone 2c, which had improved CAI activity. Compound 2c was prepared using a selective reduction and silane mediated debromination to control the relative stereochemistry of the three centers.

Full Text

Duke Authors

Cited Authors

  • McKittrick, BA; Ma, K; Dugar, S; Clader, JW; Davis, H; Czarniecki, M; McPhail, AT

Published Date

  • August 20, 1996

Published In

Volume / Issue

  • 6 / 16

Start / End Page

  • 1947 - 1950

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/0960-894X(96)00347-2

Citation Source

  • Scopus