Preparation and characterization of a new artemisinin-derived dimer
Journal Article
A new dimer (1) that is likely to be a reduction metabolite of arteether (2), the potent antimalarial agent, was prepared from deoxydihydroartemisinin (3). The identity of 1 was established from spectral data and was confirmed by X-ray crystallographic analysis. In addition, the stereochemistry of the related, previously reported dimer (4), is now more clearly defined, based on revising its X-ray crystallographic data.
Full Text
Duke Authors
Cited Authors
- Galal, AM; Ahmad, MS; El-Feraly, FS; McPhail, AT
Published Date
- October 1, 1996
Published In
Volume / Issue
- 59 / 10
Start / End Page
- 917 - 920
International Standard Serial Number (ISSN)
- 0163-3864
Digital Object Identifier (DOI)
- 10.1021/np960211a
Citation Source
- Scopus