Preparation and characterization of a new artemisinin-derived dimer

Journal Article

A new dimer (1) that is likely to be a reduction metabolite of arteether (2), the potent antimalarial agent, was prepared from deoxydihydroartemisinin (3). The identity of 1 was established from spectral data and was confirmed by X-ray crystallographic analysis. In addition, the stereochemistry of the related, previously reported dimer (4), is now more clearly defined, based on revising its X-ray crystallographic data.

Full Text

Duke Authors

Cited Authors

  • Galal, AM; Ahmad, MS; El-Feraly, FS; McPhail, AT

Published Date

  • October 1, 1996

Published In

Volume / Issue

  • 59 / 10

Start / End Page

  • 917 - 920

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np960211a

Citation Source

  • Scopus