Preparation and characterization of a new artemisinin-derived dimer
A new dimer (1) that is likely to be a reduction metabolite of arteether (2), the potent antimalarial agent, was prepared from deoxydihydroartemisinin (3). The identity of 1 was established from spectral data and was confirmed by X-ray crystallographic analysis. In addition, the stereochemistry of the related, previously reported dimer (4), is now more clearly defined, based on revising its X-ray crystallographic data.
Galal, AM; Ahmad, MS; El-Feraly, FS; McPhail, AT
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