Beta-lactams derived from the reaction of phenanthridines and 11H- dibenzo[b,e]azepin-11-one with phenyivaleryl chloride. Synthesis of fused analogs of the cholesterol absorption inhibitor Sch 48461
Phenanthridines 4 and the 11H-dibenzo[b,e]azepin-11-one 17 were used as the imine components in the ketene-imine β-lactam synthesis to provide the fused tetracyclic β-lactams 7, 8 and 18.
Afonso, A; Rosenblum, SB; Puar, MS; McPhail, AT
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