Synthesis of a C11 spirocyclopropyl derivative of 8-chloro-6,11- dihydro-5h-benzo[5,6]cyclohepta[1,2b]pyridine

Journal Article (Journal Article)

The carbanion derived from 8,11-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b] pyridine (3) reacts with methyl acrylate to form the C11 spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was required for a structure-activity study based on the lead Farnesyl Protein Transferase inhibitor 1.

Full Text

Duke Authors

Cited Authors

  • Afonso, A; Puar, MS; Kelly, J; McPhail, AT

Published Date

  • October 15, 1998

Published In

Volume / Issue

  • 39 / 42

Start / End Page

  • 7657 - 7660

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(98)01713-4

Citation Source

  • Scopus