Synthesis of a C11 spirocyclopropyl derivative of 8-chloro-6,11- dihydro-5h-benzo[5,6]cyclohepta[1,2b]pyridine
The carbanion derived from 8,11-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b] pyridine (3) reacts with methyl acrylate to form the C11 spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was required for a structure-activity study based on the lead Farnesyl Protein Transferase inhibitor 1.
Afonso, A; Puar, MS; Kelly, J; McPhail, AT
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