Structure elucidation of Sch 49088, a novel everninomicin antibiotic containing an unusual hydroxylamino-ether sugar, everhydroxylaminose

Journal Article (Journal Article)

Degradation of Sch 49088 (1) provided a novel, highly functionalized O- substituted hydroxylamine-containing sugar, everhydroxylaminose 11 isolated as a β-OMe glycoside. Notably the two acid sensitive orthoester moieties in the intact antibiotic 1 co-exist in the presence of three phenolic groups and a free carboxylic acid group.

Full Text

Duke Authors

Cited Authors

  • Saksena, AK; Jao, E; Murphy, B; Schumacher, D; Chan, TM; Puar, MS; Jenkins, JK; Maloney, D; Cordero, M; Pramanik, BN; Bartner, P; Das, PR; McPhail, AT; Girijavallabhan, VM; Ganguly, AK

Published Date

  • November 12, 1998

Published In

Volume / Issue

  • 39 / 46

Start / End Page

  • 8441 - 8444

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(98)01923-6

Citation Source

  • Scopus