Structure elucidation of Sch 49088, a novel everninomicin antibiotic containing an unusual hydroxylamino-ether sugar, everhydroxylaminose
Degradation of Sch 49088 (1) provided a novel, highly functionalized O- substituted hydroxylamine-containing sugar, everhydroxylaminose 11 isolated as a β-OMe glycoside. Notably the two acid sensitive orthoester moieties in the intact antibiotic 1 co-exist in the presence of three phenolic groups and a free carboxylic acid group.
Saksena, AK; Jao, E; Murphy, B; Schumacher, D; Chan, TM; Puar, MS; Jenkins, JK; Maloney, D; Cordero, M; Pramanik, BN; Bartner, P; Das, PR; McPhail, AT; Girijavallabhan, VM; Ganguly, AK
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