New products from the reactions of artemisinin with ammonia and amines

Published

Journal Article

Reaction of artemisinin (1) with ammonia, methylamine, dimethylamine, and allylamine afforded five unexpected products 2-6, in addition to the previously reported compounds 7-12. The identities of the new compounds were established from their spectral data, by chemical derivatization and by comparison with published reports. The stereochemistries of compounds 5 and 6 were confirmed by single-crystal X-ray analysis.

Full Text

Duke Authors

Cited Authors

  • Galal, AM; Ahmad, MS; El-Feraly, FS; McPhail, AT

Published Date

  • January 1999

Published In

Volume / Issue

  • 62 / 1

Start / End Page

  • 54 - 58

PubMed ID

  • 9917282

Pubmed Central ID

  • 9917282

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np980142v

Language

  • eng