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Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids

Publication ,  Journal Article
Guan, J; Zhu, XK; Brossi, A; Tachibana, Y; Bastow, KF; Verdier-Pinard, P; Hamel, E; McPhail, AT; Lee, KH
Published in: Collection of Czechoslovak Chemical Communications
January 1, 1999

Two allocolchicinoids 6 and 8, prepared from colchicine, together with allo compounds 9-11, made from 6 by reduction and regiodemethylation, were evaluated for antitubulin and antitumor activities. Structures of 6, 8, and 10 were confirmed by X-ray crystallographic analysis. Compounds 6, 8, and 9 have high tubulin binding affinity and display potent inhibitory activities against tubulin polymerization and solid human tumor cell lines. Particularly, drug-resistant KB cell lines, including KB-7d, KB-VCR, and KB-CPT, do not show marked resistance to these compounds.

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Published In

Collection of Czechoslovak Chemical Communications

DOI

ISSN

0010-0765

Publication Date

January 1, 1999

Volume

64

Issue

2

Start / End Page

217 / 228

Related Subject Headings

  • General Chemistry
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

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Guan, J., Zhu, X. K., Brossi, A., Tachibana, Y., Bastow, K. F., Verdier-Pinard, P., … Lee, K. H. (1999). Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids. Collection of Czechoslovak Chemical Communications, 64(2), 217–228. https://doi.org/10.1135/cccc19990217
Guan, J., X. K. Zhu, A. Brossi, Y. Tachibana, K. F. Bastow, P. Verdier-Pinard, E. Hamel, A. T. McPhail, and K. H. Lee. “Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids.” Collection of Czechoslovak Chemical Communications 64, no. 2 (January 1, 1999): 217–28. https://doi.org/10.1135/cccc19990217.
Guan J, Zhu XK, Brossi A, Tachibana Y, Bastow KF, Verdier-Pinard P, et al. Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids. Collection of Czechoslovak Chemical Communications. 1999 Jan 1;64(2):217–28.
Guan, J., et al. “Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids.” Collection of Czechoslovak Chemical Communications, vol. 64, no. 2, Jan. 1999, pp. 217–28. Scopus, doi:10.1135/cccc19990217.
Guan J, Zhu XK, Brossi A, Tachibana Y, Bastow KF, Verdier-Pinard P, Hamel E, McPhail AT, Lee KH. Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids. Collection of Czechoslovak Chemical Communications. 1999 Jan 1;64(2):217–228.

Published In

Collection of Czechoslovak Chemical Communications

DOI

ISSN

0010-0765

Publication Date

January 1, 1999

Volume

64

Issue

2

Start / End Page

217 / 228

Related Subject Headings

  • General Chemistry
  • 34 Chemical sciences
  • 03 Chemical Sciences