The asymmetric synthesis of (3R)-N-methyl-2-oxo-[1,4′-bipiperidine]-3-acetamide in quantity

Journal Article

The asymmetric synthesis of the enantiomerically pure bipiperidine core fragment of a potent dual NK1/NK2 antagonist is described. The utilization of a diastereoselective Michael addition employing Evans' auxiliary as the key step allowed for the preparation of the fragment on a multi-kilogram scale. © 2002 Published by Elsevier Science Ltd.

Full Text

Duke Authors

Cited Authors

  • Reichard, GA; Spitler, J; Mergelsberg, I; Miller, A; Wong, G; Raghavan, R; Jenkins, J; Gan, T; McPhail, AT

Published Date

  • June 24, 2002

Published In

Volume / Issue

  • 13 / 9

Start / End Page

  • 939 - 943

International Standard Serial Number (ISSN)

  • 0957-4166

Digital Object Identifier (DOI)

  • 10.1016/S0957-4166(02)00229-X

Citation Source

  • Scopus