Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Journal Article (Journal Article)
N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.
Full Text
Duke Authors
Cited Authors
- Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H
Published Date
- October 2002
Published In
Volume / Issue
- 12 / 20
Start / End Page
- 2851 - 2853
PubMed ID
- 12270161
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/s0960-894x(02)00635-2
Language
- eng