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Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.

Publication ,  Journal Article
Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H
Published in: Bioorganic & medicinal chemistry letters
October 2002

N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.

Duke Scholars

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

October 2002

Volume

12

Issue

20

Start / End Page

2851 / 2853

Related Subject Headings

  • Tumor Cells, Cultured
  • Tubulin
  • Molecular Conformation
  • Models, Molecular
  • Medicinal & Biomolecular Chemistry
  • Indicators and Reagents
  • Humans
  • Drug Screening Assays, Antitumor
  • Colchicine
  • Antineoplastic Agents
 

Citation

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MLA
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Han, S., Hamel, E., Bastow, K. F., McPhail, A. T., Brossi, A., & Lee, K.-H. (2002). Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & Medicinal Chemistry Letters, 12(20), 2851–2853. https://doi.org/10.1016/s0960-894x(02)00635-2
Han, Shiqing, Ernest Hamel, Kenneth F. Bastow, Andrew T. McPhail, Arnold Brossi, and Kuo-Hsiung Lee. “Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.Bioorganic & Medicinal Chemistry Letters 12, no. 20 (October 2002): 2851–53. https://doi.org/10.1016/s0960-894x(02)00635-2.
Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee K-H. Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & medicinal chemistry letters. 2002 Oct;12(20):2851–3.
Han, Shiqing, et al. “Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 20, Oct. 2002, pp. 2851–53. Epmc, doi:10.1016/s0960-894x(02)00635-2.
Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee K-H. Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & medicinal chemistry letters. 2002 Oct;12(20):2851–2853.
Journal cover image

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

October 2002

Volume

12

Issue

20

Start / End Page

2851 / 2853

Related Subject Headings

  • Tumor Cells, Cultured
  • Tubulin
  • Molecular Conformation
  • Models, Molecular
  • Medicinal & Biomolecular Chemistry
  • Indicators and Reagents
  • Humans
  • Drug Screening Assays, Antitumor
  • Colchicine
  • Antineoplastic Agents