Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Publication
, Journal Article
Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H
Published in: Bioorganic & medicinal chemistry letters
October 2002
N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.
Duke Scholars
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
October 2002
Volume
12
Issue
20
Start / End Page
2851 / 2853
Related Subject Headings
- Tumor Cells, Cultured
- Tubulin
- Molecular Conformation
- Models, Molecular
- Medicinal & Biomolecular Chemistry
- Indicators and Reagents
- Humans
- Drug Screening Assays, Antitumor
- Colchicine
- Antineoplastic Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Han, S., Hamel, E., Bastow, K. F., McPhail, A. T., Brossi, A., & Lee, K.-H. (2002). Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & Medicinal Chemistry Letters, 12(20), 2851–2853. https://doi.org/10.1016/s0960-894x(02)00635-2
Han, Shiqing, Ernest Hamel, Kenneth F. Bastow, Andrew T. McPhail, Arnold Brossi, and Kuo-Hsiung Lee. “Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.” Bioorganic & Medicinal Chemistry Letters 12, no. 20 (October 2002): 2851–53. https://doi.org/10.1016/s0960-894x(02)00635-2.
Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee K-H. Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & medicinal chemistry letters. 2002 Oct;12(20):2851–3.
Han, Shiqing, et al. “Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.” Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 20, Oct. 2002, pp. 2851–53. Epmc, doi:10.1016/s0960-894x(02)00635-2.
Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee K-H. Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & medicinal chemistry letters. 2002 Oct;12(20):2851–2853.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
October 2002
Volume
12
Issue
20
Start / End Page
2851 / 2853
Related Subject Headings
- Tumor Cells, Cultured
- Tubulin
- Molecular Conformation
- Models, Molecular
- Medicinal & Biomolecular Chemistry
- Indicators and Reagents
- Humans
- Drug Screening Assays, Antitumor
- Colchicine
- Antineoplastic Agents