Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.

Journal Article (Journal Article)

N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

McPhail, Andrew T.

Cited Authors

Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H

Published Date

October 2002

Published In

Bioorganic & Medicinal Chemistry Letters

Volume / Issue

12 / 20

Start / End Page

2851 - 2853

PubMed ID

12270161

Electronic International Standard Serial Number (EISSN)

1464-3405

International Standard Serial Number (ISSN)

0960-894X

Digital Object Identifier (DOI)

10.1016/s0960-894x(02)00635-2

Language

eng