Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.

Published

Journal Article

N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.

Full Text

Duke Authors

Cited Authors

  • Han, S; Hamel, E; Bastow, KF; McPhail, AT; Brossi, A; Lee, K-H

Published Date

  • October 2002

Published In

Volume / Issue

  • 12 / 20

Start / End Page

  • 2851 - 2853

PubMed ID

  • 12270161

Pubmed Central ID

  • 12270161

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(02)00635-2

Language

  • eng