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Protein phosphorylation: hormones, drugs, and bioregulation.

Publication ,  Journal Article
Shenolikar, S
Published in: FASEB J
September 1988

Reversible protein phosphorylation is widely recognized as an important mechanism for the regulation of cell function by a variety of physiological stimuli. Exposure of cells to hormones, neurotransmitters, and growth factors initiates a cascade of events facilitated by intracellular second messengers and mediated in many cases by protein kinases and/or phosphatases. The subsequent covalent modification of target proteins and the associated changes in their function account for the physiological response. Considerable evidence points to cross-talk between multiple membrane-associated signaling processes leading to coordinated regulation of cellular processes. The role of protein phosphorylation at multiple points in the pathways that integrate these signals is becoming increasingly apparent. Pharmacological modulation of cellular protein phosphorylation has yielded useful information on the molecular events involved. This review surveys some of the recent progress in hormonal regulation of cell function, focusing on examples that may provide new insight into the role of protein phosphorylation in the coordinated control of cellular processes by physiological stimuli.

Duke Scholars

Published In

FASEB J

DOI

ISSN

0892-6638

Publication Date

September 1988

Volume

2

Issue

12

Start / End Page

2753 / 2764

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Proteins
  • Protein Kinases
  • Phosphorylation
  • Phosphoprotein Phosphatases
  • Phosphatidylinositols
  • Pharmacology
  • Humans
  • Hormones
  • Enzymes
 

Citation

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Shenolikar, S. (1988). Protein phosphorylation: hormones, drugs, and bioregulation. FASEB J, 2(12), 2753–2764. https://doi.org/10.1096/fasebj.2.12.2842213
Shenolikar, S. “Protein phosphorylation: hormones, drugs, and bioregulation.FASEB J 2, no. 12 (September 1988): 2753–64. https://doi.org/10.1096/fasebj.2.12.2842213.
Shenolikar S. Protein phosphorylation: hormones, drugs, and bioregulation. FASEB J. 1988 Sep;2(12):2753–64.
Shenolikar, S. “Protein phosphorylation: hormones, drugs, and bioregulation.FASEB J, vol. 2, no. 12, Sept. 1988, pp. 2753–64. Pubmed, doi:10.1096/fasebj.2.12.2842213.
Shenolikar S. Protein phosphorylation: hormones, drugs, and bioregulation. FASEB J. 1988 Sep;2(12):2753–2764.

Published In

FASEB J

DOI

ISSN

0892-6638

Publication Date

September 1988

Volume

2

Issue

12

Start / End Page

2753 / 2764

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Proteins
  • Protein Kinases
  • Phosphorylation
  • Phosphoprotein Phosphatases
  • Phosphatidylinositols
  • Pharmacology
  • Humans
  • Hormones
  • Enzymes