Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.
Journal Article (Journal Article)
Microcystin-LR (MCYST-LR), a hepatotoxin produced by cyanobacteria, inhibited purified protein phosphatases (PrPs) from rabbit skeletal muscle and the enzymes from Aplysia with an IC50 of approximately 10(-10) M. MCYST-LR also prolonged both serotonin- (5-HT) and cyclic adenosine monophosphate-induced inward currents in sensory neurons of Aplysia. These results, which are consistent with inhibition of Aplysia PrPs, indicate that MCYST-LR may be a useful probe to elucidate the function of PrPs in neural tissues.
Full Text
Duke Authors
Cited Authors
- Ichinose, M; Endo, S; Critz, SD; Shenolikar, S; Byrne, JH
Published Date
- November 12, 1990
Published In
Volume / Issue
- 533 / 1
Start / End Page
- 137 - 140
PubMed ID
- 1964827
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/0006-8993(90)91806-r
Language
- eng
Conference Location
- Netherlands