Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.

Journal Article (Journal Article)

Microcystin-LR (MCYST-LR), a hepatotoxin produced by cyanobacteria, inhibited purified protein phosphatases (PrPs) from rabbit skeletal muscle and the enzymes from Aplysia with an IC50 of approximately 10(-10) M. MCYST-LR also prolonged both serotonin- (5-HT) and cyclic adenosine monophosphate-induced inward currents in sensory neurons of Aplysia. These results, which are consistent with inhibition of Aplysia PrPs, indicate that MCYST-LR may be a useful probe to elucidate the function of PrPs in neural tissues.

Full Text

Duke Authors

Cited Authors

  • Ichinose, M; Endo, S; Critz, SD; Shenolikar, S; Byrne, JH

Published Date

  • November 12, 1990

Published In

Volume / Issue

  • 533 / 1

Start / End Page

  • 137 - 140

PubMed ID

  • 1964827

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(90)91806-r

Language

  • eng

Conference Location

  • Netherlands