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Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins.

Publication ,  Journal Article
Minkoff, C; Shenolikar, S; Weinman, EJ
Published in: Curr Opin Nephrol Hypertens
September 1999

The sodium-hydrogen exchanger regulatory factor (NHERF) was first identified as an essential cofactor for cyclic AMP-mediated inhibition of the epithelial isoform of rabbit kidney sodium-hydrogen exchanger (NHE3). More recent work shows that NHERF constitutes a family of PSD-95/DIg/ZO-1 (PDZ) domain-containing adapter proteins, only some of which associate with the NHE3 antiporter. Other targets of the NHERF proteins include members of the ezrin-radixin-moesin family of cytoskeletal proteins. In the current model for NHE3 regulation, NHERF links NHE3 to the protein kinase A-anchoring protein, ezrin, and thereby facilitates its phosphorylation and inhibition by protein kinase A. Recent studies have also established the interaction of NHERF and its homologs with the beta2-adrenergic receptor and the platelet-derived growth factor receptor tyrosine kinase that facilitates signal transduction by these receptors. Association with NHERF may also regulate the cystic fibrosis transmembrane conductance regulator and the sodium-bicarbonate transporter. With the rapid increase in the intracellular targets identified for NHERF, the emerging data point to a broad role for these PDZ-containing proteins in the organization of signaling complexes and control of cell physiology.

Duke Scholars

Published In

Curr Opin Nephrol Hypertens

DOI

ISSN

1062-4821

Publication Date

September 1999

Volume

8

Issue

5

Start / End Page

603 / 608

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 3
  • Signal Transduction
  • Rabbits
  • Phosphoproteins
  • Mice
  • Kidney
  • Humans
  • GTP-Binding Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Minkoff, C., Shenolikar, S., & Weinman, E. J. (1999). Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr Opin Nephrol Hypertens, 8(5), 603–608. https://doi.org/10.1097/00041552-199909000-00012
Minkoff, C., S. Shenolikar, and E. J. Weinman. “Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins.Curr Opin Nephrol Hypertens 8, no. 5 (September 1999): 603–8. https://doi.org/10.1097/00041552-199909000-00012.
Minkoff C, Shenolikar S, Weinman EJ. Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr Opin Nephrol Hypertens. 1999 Sep;8(5):603–8.
Minkoff, C., et al. “Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins.Curr Opin Nephrol Hypertens, vol. 8, no. 5, Sept. 1999, pp. 603–08. Pubmed, doi:10.1097/00041552-199909000-00012.
Minkoff C, Shenolikar S, Weinman EJ. Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr Opin Nephrol Hypertens. 1999 Sep;8(5):603–608.

Published In

Curr Opin Nephrol Hypertens

DOI

ISSN

1062-4821

Publication Date

September 1999

Volume

8

Issue

5

Start / End Page

603 / 608

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 3
  • Signal Transduction
  • Rabbits
  • Phosphoproteins
  • Mice
  • Kidney
  • Humans
  • GTP-Binding Proteins