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Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation.

Publication ,  Journal Article
Voltz, JW; Weinman, EJ; Shenolikar, S
Published in: Oncogene
October 1, 2001

NHERF (Na+/H+ exchanger regulatory factor or NHERF-1) and E3KARP (NHE3 kinase A regulatory protein or NHERF-2) are structurally related protein adapters that are highly expressed in epithelial tissues. NHERF proteins contain two tandem PDZ domains and a C-terminal sequence that binds several members of the ERM (ezrin-radixin-moesin) family of membrane-cytoskeletal adapters. Although identified as a regulator of NHE3, recent evidence points to a broadening role for NHERF in the function, localization and/or turnover of G-protein coupled receptors, platelet-derived growth factor receptor and ion transporters such as CFTR, Na/Pi cotransporter, Na/HCO3 cotransporter and Trp (calcium) channels. NHERF also recruits non-membrane proteins such as the c-Yes/YAP-65 complex, members of the phospholipase Cbeta family and the GRK6A protein kinase to apical surface of polarized epithelial cells where they regulate or respond to membrane signals. While two distinct models have been proposed for NHERF's role in signal transduction, the common theme is NHERF's ability to bring together membrane and non-membrane proteins to regulate cell metabolism and growth. NHERF overexpression in human breast cancers and mutations in NHERF targets, such as CFTR and merlin, the product of Neurofibromatosis NF2 tumor suppressor gene, that impair NHERF binding suggest that aberrant NHERF function contributes to human disease.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 1, 2001

Volume

20

Issue

44

Start / End Page

6309 / 6314

Location

England

Related Subject Headings

  • Sodium-Hydrogen Exchangers
  • Signal Transduction
  • Protein Structure, Tertiary
  • Protein Binding
  • Phosphorylation
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Models, Biological
  • Humans
 

Citation

APA
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MLA
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Voltz, J. W., Weinman, E. J., & Shenolikar, S. (2001). Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene, 20(44), 6309–6314. https://doi.org/10.1038/sj.onc.1204774
Voltz, J. W., E. J. Weinman, and S. Shenolikar. “Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation.Oncogene 20, no. 44 (October 1, 2001): 6309–14. https://doi.org/10.1038/sj.onc.1204774.
Voltz JW, Weinman EJ, Shenolikar S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene. 2001 Oct 1;20(44):6309–14.
Voltz, J. W., et al. “Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation.Oncogene, vol. 20, no. 44, Oct. 2001, pp. 6309–14. Pubmed, doi:10.1038/sj.onc.1204774.
Voltz JW, Weinman EJ, Shenolikar S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene. 2001 Oct 1;20(44):6309–6314.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 1, 2001

Volume

20

Issue

44

Start / End Page

6309 / 6314

Location

England

Related Subject Headings

  • Sodium-Hydrogen Exchangers
  • Signal Transduction
  • Protein Structure, Tertiary
  • Protein Binding
  • Phosphorylation
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Models, Biological
  • Humans