Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters.

Journal Article (Journal Article)

Two broad-specifically protein phosphatases, termed protein phosphatase-1 (PrP-1) and protein phosphatase-2A (PrP-2A), accounting for all the hepatic activity regulating glycogen phosphorylase, were measured in spontaneously diabetic Chinese hamsters exhibiting persistent glycosuria. When compared with genetically related inbred sublines free of glycosuria, diabetic animals demonstrated approximately 25% increase in PrP-1 activity measured either in crude tissue extracts or in cytosols fractionated by ion-exchange chromatography. No significant alteration in total PrP-2A activity was observed in the diabetic animals. These findings indicate that a specific change in hepatic PrP-1 is associated with genetically acquired diabetes in Chinese hamsters. In contrast to reported data using animals with experimentally induced diabetes mellitus, hepatic PrP-1 was increased in the spontaneously diabetic Chinese hamsters. The data suggests that distinct alterations in PrP-1 and associated metabolic consequences are exhibited by different types of diabetes.

Full Text

Duke Authors

Cited Authors

  • Hanley, RM; Strada, SJ; Steiner, AL; Thompson, WJ; Shenolikar, S

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 50 / 1-2

Start / End Page

  • 115 - 122

PubMed ID

  • 3034694

International Standard Serial Number (ISSN)

  • 0303-7207

Digital Object Identifier (DOI)

  • 10.1016/0303-7207(87)90083-9


  • eng

Conference Location

  • Ireland